Change in autoantibody and cytokine responses during the evolution of neuromyelitis optica in patients with systemic lupus erythematosus: A preliminary study.

Kovacs, Katalin T; Kalluri, Sudhakar Reddy; Boza-Serrano, Antonio; Deierborg, Tomas; Csepany, Tunde; Simo, Magdolna; Rokusz, Laszlo; Miseta, Attila; Alcaraz, Nicolas; Czirják, László; Berki, Timea; Molnar, Tihamer; Hemmer, Bernhard; Illes, Zsolt

doi:10.1177/1352458515613165

journal article

Titel:: Change in autoantibody and cytokine responses during the evolution of neuromyelitis optica in patients with systemic lupus erythematosus: A preliminary study.
Dokumenttyp:: Journal Article; Article
Autor(en):: Kovacs, Katalin T; Kalluri, Sudhakar Reddy; Boza-Serrano, Antonio; Deierborg, Tomas; Csepany, Tunde; Simo, Magdolna; Rokusz, Laszlo; Miseta, Attila; Alcaraz, Nicolas; Czirják, László; Berki, Timea; Molnar, Tihamer; Hemmer, Bernhard; Illes, Zsolt
Abstract:: Neuromyelitis optica (NMO)-systemic lupus erythematosus (SLE) association is a rare condition characterized by multiple autoantibodies.To examine if, during the evolution of NMO, anti-AQP4 responses are part of polyclonal B cell activation, and if T cell responses contribute.In 19 samples of six patients who developed NMO during SLE, we examined the correlation of AQP4-IgG1 and IgM with (i) anti-MOG IgG and IgM, (ii) anti-nuclear, anti-nucleosome and anti-dsDNA IgG antibodies, (iii) cytokines and chemokines in the serum and (iv) longitudinal relation to NMO relapses/remission.AQP4-IgG1 was present 1-2-5 years before the first NMO relapse. During relapse, AQP4-IgG1, ANA, anti-dsDNA and anti-nucleosome antibodies were elevated. Anti-MOG IgG/IgM and AQP4-IgM antibodies were not detected. AQP4-IgG1 antibodies correlated with concentration of anti-nucleosome, IFN-?,interferon-gamma-induced CCL10/IP-10 and CCL17/TARC (p<0.05, respectively). CCL17/TARC correlated with levels of anti-nucleosome and anti-dsDNA (p<0.05, respectively). Compared to healthy subjects, concentration of IFN-? and CCL17/TARC was higher in NMO/SLE (p<0.05).AQP4-IgG1 antibodies are present in the sera years before the first NMO attack in patients with SLE; elevation of anti-AQP4 is part of a polyclonal B cell response during NMO relapses; in spite of multiple autoantibodies in the serum, MOG antibodies were not present; Th1 responses accompany autoantibody responses in NMO/SLE.
Zeitschriftentitel:: Mult Scler
Jahr:: 2016
Band / Volume:: 22
Heft / Issue:: 9
Seitenangaben Beitrag:: 1192-201
Sprache:: eng
Volltext / DOI:: doi:10.1177/1352458515613165
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/26514978
Print-ISSN:: 1352-4585
TUM Einrichtung:: Neurologische Klinik und Poliklinik
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Neurologie (Prof. Hemmer)2016