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Titel:

Effects of delayed-release dimethyl fumarate on MRI measures in the phase 3 CONFIRM study.

Dokumenttyp:
journal article
Autor(en):
Miller, David H; Fox, Robert J; Phillips, J Theodore; Hutchinson, Michael; Havrdova, Eva; Kita, Mariko; Wheeler-Kingshott, Claudia A M; Tozer, Daniel J; MacManus, David G; Yousry, Tarek A; Goodsell, Mary; Yang, Minhua; Zhang, Ray; Viglietta, Vissia; Dawson, Katherine T; CONFIRM study investigators; Fox, Robert J; Phillips, J Theodore; Hutchinson, Michael; Havrdova, Eva; Kita, Mariko; Wilson, Kate; Yang, Minhua; Dawson, Katherine T; Antel, Jack; Ware, James; Polman, Chris; Kowey, Peter R; Chung,...     »
Abstract:
To evaluate the effects of oral delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF) on MRI lesion activity and load, atrophy, and magnetization transfer ratio (MTR) measures from the Comparator and an Oral Fumarate in Relapsing-Remitting Multiple Sclerosis (CONFIRM) study.CONFIRM was a 2-year, placebo-controlled study of the efficacy and safety of DMF 240 mg twice (BID) or 3 times daily (TID) in 1,417 patients with relapsing-remitting multiple sclerosis (RRMS); subcutan...     »
Zeitschriftentitel:
Neurology
Jahr:
2015
Band / Volume:
84
Heft / Issue:
11
Seitenangaben Beitrag:
1145-52
Sprache:
eng
Volltext / DOI:
doi:10.1212/WNL.0000000000001360
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25681448
Print-ISSN:
0028-3878
TUM Einrichtung:
Neurologische Klinik und Poliklinik
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