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Document type:
Journal Article; Article 
Author(s):
Daryadel, Arezoo; Haubitz, Monika; Figueiredo, Marta; Steubl, Dominik; Roos, Marcel; Mäder, Armin; Hettwer, Stefan; Wagner, Carsten A 
Title:
The C-Terminal Fragment of Agrin (CAF), a Novel Marker of Renal Function, Is Filtered by the Kidney and Reabsorbed by the Proximal Tubule. 
Abstract:
Agrin, a multidomain proteoglycan and neurotrypsin, a neuronal serine protease, are important for forming (neuromuscular) synapses. Proteolytical activity of neurotrypsin produces a C-terminal fragment of agrin, termed CAF, of approximately 22 kDA molecular size which also circulates in blood. The presence of CAF in urine suggests either glomerular filtration or secretion into urine. Blood levels of CAF have been identified as a potential novel marker of kidney function. Here we describe that se...    »
 
Journal title abbreviation:
PLoS ONE 
Year:
2016 
Journal volume:
11 
Journal issue:
Pages contribution:
e0157905 
Language:
eng 
Print-ISSN:
1932-6203 
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann)