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- Dokumenttyp:
- Journal Article; Article
- Autor(en):
- Steubl, Dominik; Vogel, Anna; Hettwer, Stefan; Tholen, Susanne; Luppa, Peter B; Rondak, Ina-Christine; Renders, Lutz; Heemann, Uwe; Roos, Marcel
- Titel:
- Early postoperative C-terminal agrin fragment (CAF) serum levels predict graft loss and proteinuria in renal transplant recipients.
- Abstract:
- C-terminal agrin fragment (CAF), cleavage product of agrin, was previously correlated with kidney function in renal transplant patients. This article studies the predictive value of CAF for long-term outcomes in renal transplant recipients.In this observational cohort study, serum CAF, creatinine and blood-urea-nitrogen (BUN) concentrations and eGFR (CKD-EPI) were assessed 1-3 months after transplantation in 105 patients undergoing kidney transplantation. Cox regression models were used to analyse the predictive value of all parameters concerning all-cause mortality (ACM), graft loss (GL), doubling of creatinine/proteinuria at the end of follow-up.Median follow-up time was 3.1 years. The mean concentrations were 191.9±152.4 pM for CAF, 176±96.8 ?mol/L for creatinine, 12.6±6.2 mmol/L for BUN and 44.9±21.2 mL/min for CKD-EPI formula, respectively. In univariate analysis CAF and BUN concentrations predicted ACM (CAF: HR=1.003, 1.1-fold risk, p=0.043; BUN: HR=1.037, 1.3-fold risk, p=0.006). Concerning GL, CAF (HR=1.006, 3.1-fold risk, p<0.001), creatinine (HR=2.396, 2.6-fold risk, p<0.001), BUN (HR=1.048, 1.7-fold risk, p=0.001) and eGFR (CKD-EPI) (HR=0.941, 0.45-fold risk reduction, p=0.006) showed a statistically significant association. CAF was the only parameter significantly associated with doubling of proteinuria (HR=1.005, 1.7-fold risk, p<0.001). In multiple regression analysis (CAF only) the association remained significant for GL and doubling of proteinuria but not ACM.Early postoperative serum CAF appears to be a useful tool for the assessment of long-term outcomes in renal transplant recipients. Most importantly it represents a promising predictor for the development of proteinuria.
- Zeitschriftentitel:
- Clin Chem Lab Med
- Jahr:
- 2016
- Band / Volume:
- 54
- Heft / Issue:
- 1
- Seitenangaben Beitrag:
- 63-72
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1515/cclm-2015-0369
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/26087066
- Print-ISSN:
- 1434-6621
- TUM Einrichtung:
- Fachgebiet Nephrologie (Prof. Heemann)
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