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- Dokumenttyp:
- Journal Article; Article
- Autor(en):
- Kemmner, Stephan; Schulte, Christian; Hann von Weyhern, Claus; Schmidt, Roland; Baumann, Marcus; Heemann, Uwe; Renders, Lutz; Schmaderer, Christoph
- Titel:
- EMMPRIN expression is involved in the development of interstitial fibrosis and tubular atrophy in human kidney allografts.
- Abstract:
- Matrix metalloproteinases (MMP) are involved in the development of interstitial fibrosis and tubular atrophy (IF/TA) in renal disease. The synthesis of MMP is activated by the extracellular matrix metalloproteinases inducer protein (EMMPRIN). To analyze the role of EMMPRIN in IF/TA, we retrospectively detected EMMPRIN expression in specimens of human renal allografts with various levels of IF/TA.Immunohistochemistry was performed to detect EMMPRIN expression. In a retrospective analysis, a total cohort of 50 specimens were divided according to BANFF-classification into four subgroups (0-3): no, mild (<=25%), moderate (26-50%), or severe (>50%) IF/TA. Among other parameters, renal function was analyzed and compared to EMMPRIN expression.In 24 of 38 biopsies, we detected positive EMMPRIN staining. All nephrectomy (n = 12) samples were negative for EMMPRIN. Positive staining in the biopsy samples was detectable on the basolateral side of tubular epithelial cells. EMMPRIN staining was negatively correlated with IF/TA (p < 0.001). We found significant differences between the mean EMMPRIN expression in IF/TA groups 0 and 3 (p = 0.021) and groups 1 and 3 (p = 0.004). Furthermore, we found significant correlations between EMMPRIN staining and renal function.Our data suggest that EMMPRIN is involved in the pathophysiology of IF/TA.
- Zeitschriftentitel:
- Clin Transplant
- Jahr:
- 2016
- Band / Volume:
- 30
- Heft / Issue:
- 3
- Seitenangaben Beitrag:
- 218-25
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1111/ctr.12677
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/26659824
- Print-ISSN:
- 0902-0063
- TUM Einrichtung:
- Fachgebiet Nephrologie (Prof. Heemann)
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