EMMPRIN expression is involved in the development of interstitial fibrosis and tubular atrophy in human kidney allografts.

Kemmner, Stephan; Schulte, Christian; Hann von Weyhern, Claus; Schmidt, Roland; Baumann, Marcus; Heemann, Uwe; Renders, Lutz; Schmaderer, Christoph

doi:10.1111/ctr.12677

2016

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Title:: EMMPRIN expression is involved in the development of interstitial fibrosis and tubular atrophy in human kidney allografts.
Document type:: Journal Article; Article
Author(s):: Kemmner, Stephan; Schulte, Christian; Hann von Weyhern, Claus; Schmidt, Roland; Baumann, Marcus; Heemann, Uwe; Renders, Lutz; Schmaderer, Christoph
Abstract:: Matrix metalloproteinases (MMP) are involved in the development of interstitial fibrosis and tubular atrophy (IF/TA) in renal disease. The synthesis of MMP is activated by the extracellular matrix metalloproteinases inducer protein (EMMPRIN). To analyze the role of EMMPRIN in IF/TA, we retrospectively detected EMMPRIN expression in specimens of human renal allografts with various levels of IF/TA.Immunohistochemistry was performed to detect EMMPRIN expression. In a retrospective analysis, a total cohort of 50 specimens were divided according to BANFF-classification into four subgroups (0-3): no, mild (<=25%), moderate (26-50%), or severe (>50%) IF/TA. Among other parameters, renal function was analyzed and compared to EMMPRIN expression.In 24 of 38 biopsies, we detected positive EMMPRIN staining. All nephrectomy (n = 12) samples were negative for EMMPRIN. Positive staining in the biopsy samples was detectable on the basolateral side of tubular epithelial cells. EMMPRIN staining was negatively correlated with IF/TA (p < 0.001). We found significant differences between the mean EMMPRIN expression in IF/TA groups 0 and 3 (p = 0.021) and groups 1 and 3 (p = 0.004). Furthermore, we found significant correlations between EMMPRIN staining and renal function.Our data suggest that EMMPRIN is involved in the pathophysiology of IF/TA.
Journal title abbreviation:: Clin Transplant
Year:: 2016
Journal volume:: 30
Journal issue:: 3
Pages contribution:: 218-25
Language:: eng
Fulltext / DOI:: doi:10.1111/ctr.12677
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/26659824
Print-ISSN:: 0902-0063
TUM Institution:: Fachgebiet Nephrologie (Prof. Heemann)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Innere Medizin II, Gastroenterologie (Prof. Schmid)Abteilung für Nephrologie (Prof. Heemann)Professur für Nephrologie (Prof. Heemann)2016