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Titel:

Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Chen, Liye; Ridley, Anna; Hammitzsch, Ariane; Al-Mossawi, Mohammad Hussein; Bunting, Helen; Georgiadis, Dimitris; Chan, Antoni; Kollnberger, Simon; Bowness, Paul
Abstract:
Human leucocyte antigen (HLA)-B27 and endoplasmic reticulum aminopeptidase 1 (ERAP1) are strongly associated with ankylosing spondylitis (AS). ERAP1 is a key aminopeptidase in HLA class I presentation and can potentially alter surface expression of HLA-B27 free heavy chains (FHCs). We studied the effects of ERAP1 silencing/inhibition/variations on HLA-B27 FHC expression and Th17 responses in AS.Flow cytometry was used to measure surface expression of HLA class I in peripheral blood mononuclear c...     »
Zeitschriftentitel:
Ann Rheum Dis
Jahr:
2016
Band / Volume:
75
Heft / Issue:
5
Seitenangaben Beitrag:
916-23
Sprache:
eng
Volltext / DOI:
doi:10.1136/annrheumdis-2014-206996
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26130142
Print-ISSN:
0003-4967
TUM Einrichtung:
Fachgebiet Nephrologie (Prof. Heemann)
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