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Titel:

The C-Terminal Fragment of Agrin (CAF), a Novel Marker of Renal Function, Is Filtered by the Kidney and Reabsorbed by the Proximal Tubule.

Dokumenttyp:
Journal Article; Article
Autor(en):
Daryadel, Arezoo; Haubitz, Monika; Figueiredo, Marta; Steubl, Dominik; Roos, Marcel; Mäder, Armin; Hettwer, Stefan; Wagner, Carsten A
Abstract:
Agrin, a multidomain proteoglycan and neurotrypsin, a neuronal serine protease, are important for forming (neuromuscular) synapses. Proteolytical activity of neurotrypsin produces a C-terminal fragment of agrin, termed CAF, of approximately 22 kDA molecular size which also circulates in blood. The presence of CAF in urine suggests either glomerular filtration or secretion into urine. Blood levels of CAF have been identified as a potential novel marker of kidney function. Here we describe that se...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2016
Band / Volume:
11
Heft / Issue:
7
Seitenangaben Beitrag:
e0157905
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0157905
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27380275
Print-ISSN:
1932-6203
TUM Einrichtung:
Fachgebiet Nephrologie (Prof. Heemann)
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