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Titel:

Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies.

Dokumenttyp:
Journal Article; 1
Autor(en):
McKerrell, Thomas; Moreno, Thaidy; Ponstingl, Hannes; Bolli, Niccolo; Dias, João M L; Tischler, German; Colonna, Vincenza; Manasse, Bridget; Bench, Anthony; Bloxham, David; Herman, Bram; Fletcher, Danielle; Park, Naomi; Quail, Michael A; Manes, Nicla; Hodkinson, Clare; Baxter, Joanna; Sierra, Jorge; Foukaneli, Theodora; Warren, Alan J; Chi, Jianxiang; Costeas, Paul; Rad, Roland; Huntly, Brian; Grove, Carolyn; Ning, Zemin; Tyler-Smith, Chris; Varela, Ignacio; Scott, Mike; Nomdedeu, Josep; Mustone...     »
Abstract:
The diagnosis of hematologic malignancies relies on multidisciplinary workflows involving morphology, flow cytometry, cytogenetic, and molecular genetic analyses. Advances in cancer genomics have identified numerous recurrent mutations with clear prognostic and/or therapeutic significance to different cancers. In myeloid malignancies, there is a clinical imperative to test for such mutations in mainstream diagnosis; however, progress toward this has been slow and piecemeal. Here we describe Kar...     »
Zeitschriftentitel:
Blood
Jahr:
2016
Band / Volume:
128
Heft / Issue:
1
Seitenangaben Beitrag:
e1-9
Sprache:
eng
Volltext / DOI:
doi:10.1182/blood-2015-11-683334
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27121471
Print-ISSN:
0006-4971
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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