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Title:

Targeting PI3K/mTOR Signaling Displays Potent Antitumor Efficacy against Nonfunctioning Pituitary Adenomas.

Document type:
journal article
Author(s):
Lee, Misu, M; Wiedemann, Tobias, T; Gross, Claudia, C; Leinhäuser, Ines, I; Roncaroli, Federico, F; Braren, Rickmer, R; Pellegata, Natalia S, NS
Abstract:
Novel therapeutic approaches are needed to improve the postoperative management of residual nonfunctioning pituitary adenomas (NFPA), given their high relapse rate. Here, we evaluated the antitumor efficacy of the dual PI3K/mTOR inhibitor NVP-BEZ235 in the only available model of spontaneous NFPAs (MENX rats).Organotypic cultures of rat primary NFPAs were incubated with NVP-BEZ235 and assessed for cell viability, proliferation, apoptosis, and PI3K/mTOR inhibition. NVP-BEZ235, or placebo, was adm...     »
Journal title abbreviation:
Clin Cancer Res
Year:
2015
Journal volume:
21
Journal issue:
14
Pages contribution:
3204-15
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25838390
Print-ISSN:
1078-0432
TUM Institution:
Institut für Radiologie
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