Benutzer: Gast  Login
Titel:

MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease.

Dokumenttyp:
Journal Article; Article
Autor(en):
Hartmann, Dorothee; Fiedler, Jan; Sonnenschein, Kristina; Just, Annette; Pfanne, Angelika; Zimmer, Karina; Remke, Janet; Foinquinos, Ariana; Butzlaff, Malte; Schimmel, Katharina; Maegdefessel, Lars; Hilfiker-Kleiner, Denise; Lachmann, Nico; Schober, Andreas; Froese, Natali; Heineke, Jörg; Bauersachs, Johann; Batkai, Sandor; Thum, Thomas
Abstract:
The transcription factor GATA2 orchestrates the expression of many endothelial-specific genes, illustrating its crucial importance for endothelial cell function. The capacity of this transcription factor in orchestrating endothelial-important microRNAs (miRNAs/miR) is unknown.Endothelial GATA2 was functionally analyzed in human endothelial cells in vitro. Endogenous short interfering RNA-mediated knockdown and lentiviral-based overexpression were applied to decipher the capacity of GATA2 in regu...     »
Zeitschriftentitel:
Circulation
Jahr:
2016
Band / Volume:
134
Heft / Issue:
24
Seitenangaben Beitrag:
1973-1990
Sprache:
eng
Volltext / DOI:
doi:10.1161/CIRCULATIONAHA.116.022478
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27780851
Print-ISSN:
0009-7322
TUM Einrichtung:
Fachgebiet Gefäßchirurgie (Prof. Eckstein)
 BibTeX