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Title:

NLRP3 and ASC suppress lupus-like autoimmunity by driving the immunosuppressive effects of TGF-? receptor signalling.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Lech, Maciej; Lorenz, Georg; Kulkarni, Onkar P; Grosser, Marian O O; Stigrot, Nora; Darisipudi, Murthy N; Günthner, Roman; Wintergerst, Maximilian W M; Anz, David; Susanti, Heni Eka; Anders, Hans-Joachim
Abstract:
The NLRP3/ASC inflammasome drives host defence and autoinflammatory disorders by activating caspase-1 to trigger the secretion of mature interleukin (IL)-1?/IL-18, but its potential role in autoimmunity is speculative.We generated and phenotyped Nlrp3-deficient, Asc-deficient, Il-1r-deficient and Il-18-deficient C57BL/6-lpr/lpr mice, the latter being a mild model of spontaneous lupus-like autoimmunity.While lack of IL-1R or IL-18 did not affect the C57BL/6-lpr/lpr phenotype, lack of NLRP3 or ASC...     »
Journal title abbreviation:
Ann Rheum Dis
Year:
2015
Journal volume:
74
Journal issue:
12
Pages contribution:
2224-35
Language:
eng
Fulltext / DOI:
doi:10.1136/annrheumdis-2014-205496
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25135254
Print-ISSN:
0003-4967
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann)
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