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Titel:

Obesity-associated hypertension is ameliorated in patients with TLR4 single nucleotide polymorphism (SNP) rs4986790.

Dokumenttyp:
Journal Article; Article
Autor(en):
Schneider, Simon; Hoppmann, Petra; Koch, Werner; Kemmner, Stephan; Schmaderer, Christoph; Renders, Lutz; Kastrati, Adnan; Laugwitz, Karl-Ludwig; Heemann, Uwe; Baumann, Marcus
Abstract:
Obesity is strongly associated with hypertension. Despite numerous mechanistic links the association is not fully understood. Western diet increases uptake of Toll-Like receptor 4 (TLR4) ligands such as free fatty acids or endotoxin. We recently demonstrated that TLR4 ligands are involved in the development of hypertension. We hypothesized that TLR4 ligands are involved in obesity-associated hypertension and investigated the TLR4 single nucleotide polymorphism (SNP rs 498790). This SNP is freque...     »
Zeitschriftentitel:
J Inflamm (Lond)
Jahr:
2015
Band / Volume:
12
Seitenangaben Beitrag:
57
Sprache:
eng
Volltext / DOI:
doi:10.1186/s12950-015-0100-5
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26435700
TUM Einrichtung:
Fachgebiet Nephrologie (Prof. Heemann); I. Medizinische Klinik und Poliklinik (Kardiologie); Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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