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Titel:

CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Hammitzsch, Ariane; Tallant, Cynthia; Fedorov, Oleg; O'Mahony, Alison; Brennan, Paul E; Hay, Duncan A; Martinez, Fernando O; Al-Mossawi, M Hussein; de Wit, Jelle; Vecellio, Matteo; Wells, Christopher; Wordsworth, Paul; Müller, Susanne; Knapp, Stefan; Bowness, Paul
Abstract:
Th17 responses are critical to a variety of human autoimmune diseases, and therapeutic targeting with monoclonal antibodies against IL-17 and IL-23 has shown considerable promise. Here, we report data to support selective bromodomain blockade of the transcriptional coactivators CBP (CREB binding protein) and p300 as an alternative approach to inhibit human Th17 responses. We show that CBP30 has marked molecular specificity for the bromodomains of CBP and p300, compared with 43 other bromodomains...     »
Zeitschriftentitel:
Proc Natl Acad Sci U S A
Jahr:
2015
Band / Volume:
112
Heft / Issue:
34
Seitenangaben Beitrag:
10768-73
Volltext / DOI:
doi:10.1073/pnas.1501956112
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26261308
Print-ISSN:
0027-8424
TUM Einrichtung:
Fachgebiet Nephrologie (Prof. Heemann)
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