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Titel:

Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers.

Dokumenttyp:
Journal Article; Article
Autor(en):
Peterlongo, Paolo; Chang-Claude, Jenny; Moysich, Kirsten B; Rudolph, Anja; Schmutzler, Rita K; Simard, Jacques; Soucy, Penny; Eeles, Rosalind A; Easton, Douglas F; Hamann, Ute; Wilkening, Stefan; Chen, Bowang; Rookus, Matti A; Schmidt, Marjanka K; van der Baan, Frederieke H; Spurdle, Amanda B; Walker, Logan C; Lose, Felicity; Maia, Ana-Teresa; Montagna, Marco; Matricardi, Laura; Lubinski, Jan; Jakubowska, Anna; Gómez Garcia, Encarna B; Olopade, Olufunmilayo I; Nussbaum, Robert L; Nathanson, Kath...     »
Abstract:
BRCA1 and BRCA2 mutation carriers are at substantially increased risk for developing breast and ovarian cancer. The incomplete penetrance coupled with the variable age at diagnosis in carriers of the same mutation suggests the existence of genetic and nongenetic modifying factors. In this study, we evaluated the putative role of variants in many candidate modifier genes.Genotyping data from 15,252 BRCA1 and 8,211 BRCA2 mutation carriers, for known variants (n = 3,248) located within or around 44...     »
Zeitschriftentitel:
Cancer Epidemiol Biomarkers Prev
Jahr:
2015
Band / Volume:
24
Heft / Issue:
1
Seitenangaben Beitrag:
308-16
Sprache:
eng
Volltext / DOI:
doi:10.1158/1055-9965.EPI-14-0532
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25336561
Print-ISSN:
1055-9965
TUM Einrichtung:
Frauenklinik und Poliklinik
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