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Titel:

Opposing role of Notch1 and Notch2 in a Kras(G12D)-driven murine non-small cell lung cancer model.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Baumgart, A; Mazur, P K; Anton, M; Rudelius, M; Schwamborn, K; Feuchtinger, A; Behnke, K; Walch, A; Braren, R; Peschel, C; Duyster, J; Siveke, J T; Dechow, T
Abstract:
Lung cancer is the leading cause of cancer-related deaths worldwide. Recently, we have shown that Notch1 inhibition resulted in substantial cell death of non-small cell lung cancer (NSCLC) cells in vitro. New compounds targeting Notch signal transduction have been developed and are now being tested in clinical trials. However, the tumorigenic role of individual Notch receptors in vivo remains largely unclear. Using a Kras(G12D)-driven endogenous NSCLC mouse model, we analyzed the effect of condi...     »
Zeitschriftentitel:
Oncogene
Jahr:
2015
Band / Volume:
34
Heft / Issue:
5
Seitenangaben Beitrag:
578-88
Sprache:
eng
Volltext / DOI:
doi:10.1038/onc.2013.592
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24509876
Print-ISSN:
0950-9232
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Experimentelle Onkologie und Therapieforschung
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