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Title:

Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression.

Document type:
Journal Article; Article
Author(s):
Darabi, Hatef; McCue, Karen; Beesley, Jonathan; Michailidou, Kyriaki; Nord, Silje; Kar, Siddhartha; Humphreys, Keith; Thompson, Deborah; Ghoussaini, Maya; Bolla, Manjeet K; Dennis, Joe; Wang, Qin; Canisius, Sander; Scott, Christopher G; Apicella, Carmel; Hopper, John L; Southey, Melissa C; Stone, Jennifer; Broeks, Annegien; Schmidt, Marjanka K; Scott, Rodney J; Lophatananon, Artitaya; Muir, Kenneth; Beckmann, Matthias W; Ekici, Arif B; Fasching, Peter A; Heusinger, Katharina; dos-Santos-Silva, I...     »
Abstract:
Genome-wide association studies have identified SNPs near ZNF365 at 10q21.2 that are associated with both breast cancer risk and mammographic density. To identify the most likely causal SNPs, we fine mapped the association signal by genotyping 428 SNPs across the region in 89,050 European and 12,893 Asian case and control subjects from the Breast Cancer Association Consortium. We identified four independent sets of correlated, highly trait-associated variants (iCHAVs), three of which were locate...     »
Journal title abbreviation:
Am J Hum Genet
Year:
2015
Journal volume:
97
Journal issue:
1
Pages contribution:
22-34
Language:
eng
Fulltext / DOI:
doi:10.1016/j.ajhg.2015.05.002
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26073781
Print-ISSN:
0002-9297
TUM Institution:
Frauenklinik und Poliklinik
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