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Title:

Fine-scale mapping of the 4q24 locus identifies two independent loci associated with breast cancer risk.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Article
Author(s):
Guo, Xingyi; Long, Jirong; Zeng, Chenjie; Michailidou, Kyriaki; Ghoussaini, Maya; Bolla, Manjeet K; Wang, Qin; Milne, Roger L; Shu, Xiao-Ou; Cai, Qiuyin; Beesley, Jonathan; Kar, Siddhartha P; Andrulis, Irene L; Anton-Culver, Hoda; Arndt, Volker; Beckmann, Matthias W; Beeghly-Fadiel, Alicia; Benitez, Javier; Blot, William; Bogdanova, Natalia; Bojesen, Stig E; Brauch, Hiltrud; Brenner, Hermann; Brinton, Louise; Broeks, Annegien; Brüning, Thomas; Burwinkel, Barbara; Cai, Hui; Canisius, Sander; Chan...     »
Abstract:
A recent association study identified a common variant (rs9790517) at 4q24 to be associated with breast cancer risk. Independent association signals and potential functional variants in this locus have not been explored.We conducted a fine-mapping analysis in 55,540 breast cancer cases and 51,168 controls from the Breast Cancer Association Consortium.Conditional analyses identified two independent association signals among women of European ancestry, represented by rs9790517 [conditional P = 2.5...     »
Journal title abbreviation:
Cancer Epidemiol Biomarkers Prev
Year:
2015
Journal volume:
24
Journal issue:
11
Pages contribution:
1680-91
Language:
eng
Fulltext / DOI:
doi:10.1158/1055-9965.EPI-15-0363
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26354892
Print-ISSN:
1055-9965
TUM Institution:
Frauenklinik und Poliklinik
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