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Title:

Alternation of histone and DNA methylation in human atherosclerotic carotid plaques.

Document type:
Journal Article; 2
Author(s):
Greißel, A; Culmes, M; Napieralski, R; Wagner, E; Gebhard, H; Schmitt, M; Zimmermann, A; Eckstein, H-H; Zernecke, A; Pelisek, J
Abstract:
Little is known about epigenetics and its possible role in atherosclerosis. We here analysed histone and DNA methylation and the expression of corresponding methyltransferases in early and advanced human atherosclerotic carotid lesions in comparison to healthy carotid arteries. Western Blotting was performed on carotid plaques from our biobank with early (n=60) or advanced (n=60) stages of atherosclerosis and healthy carotid arteries (n=12) to analyse di-methylation patterns of histone H3 at pos...     »
Journal title abbreviation:
Thromb Haemost
Year:
2015
Journal volume:
114
Journal issue:
2
Pages contribution:
390-402
Language:
eng
Fulltext / DOI:
doi:10.1160/TH14-10-0852
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25993995
Print-ISSN:
0340-6245
TUM Institution:
Fachgebiet Gefäßchirurgie (Prof. Eckstein)
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