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Title:

CD8+ T Cells Regulate Monopoiesis and Circulating Ly6C-high Monocyte Levels in Atherosclerosis in Mice.

Document type:
Journal Article; Research Support, N.I.H., Extramural; 3
Author(s):
Cochain, Clément; Koch, Miriam; Chaudhari, Sweena M; Busch, Martin; Pelisek, Jaroslav; Boon, Louis; Zernecke, Alma
Abstract:
Proinflammatory adaptive immune responses are recognized as major drivers of atherosclerotic lesion formation. Although CD8(+) T cells have recently been proposed as a proatherogenic cell subset, their full scope of actions remains to be elucidated.We here addressed the contribution of CD8(+) T cells to monocyte trafficking in atherosclerosis.We observed that CD8(+) T cells express proinflammatory cytokines (interferon-?, tumor necrosis factor-?, and interleukin-12) within atherosclerotic lesion...     »
Journal title abbreviation:
Circ Res
Year:
2015
Journal volume:
117
Journal issue:
3
Pages contribution:
244-53
Language:
eng
Fulltext / DOI:
doi:10.1161/CIRCRESAHA.117.304611
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25991812
Print-ISSN:
0009-7330
TUM Institution:
Fachgebiet Gefäßchirurgie (Prof. Eckstein)
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