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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Kong, Bo; Wu, Weiwei; Valkovska, Nataliya; Jäger, Carsten; Hong, Xin; Nitsche, Ulrich; Friess, Helmut; Esposito, Irene; Erkan, Mert; Kleeff, Jörg; Michalski, Christoph W
Titel:
A common genetic variation of melanoma inhibitory activity-2 labels a subtype of pancreatic adenocarcinoma with high endoplasmic reticulum stress levels.
Abstract:
HNF1 homeobox A (HNF1A)-mediated gene expression constitutes an essential component of the secretory pathway in the exocrine pancreas. Melanoma inhibitory activity 2 (MIA2), a protein facilitating protein secretion, is an HNF1A target. Protein secretion is precisely coordinated by the endoplasmic reticulum (ER) stress/unfolded protein response (UPR) system. Here, we demonstrate that HNFA and MIA2 are expressed in a subset of human PDAC tissues and that HNF1A induced MIA2 in vitro. We identified...     »
Zeitschriftentitel:
Sci Rep
Jahr:
2015
Band / Volume:
5
Seitenangaben Beitrag:
8109
Sprache:
eng
Volltext / DOI:
doi:10.1038/srep08109
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25657029
Print-ISSN:
2045-2322
TUM Einrichtung:
Chirurgische Klinik und Poliklinik
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