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Title:

Tissue inhibitor of metalloproteinases (TIMP)-1 creates a premetastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Author(s):
Seubert, Bastian; Grünwald, Barbara; Kobuch, Julia; Cui, Haissi; Schelter, Florian; Schaten, Susanne; Siveke, Jens T; Lim, Ngee H; Nagase, Hideaki; Simonavicius, Nicole; Heikenwälder, Mathias; Reinheckel, Thomas; Sleeman, Jonathan P; Janssen, Klaus-Peter; Knolle, Percy A; Krüger, Achim
Abstract:
Due to its ability to inhibit prometastatic matrix metalloproteinases, tissue inhibitor of metalloproteinases (TIMP)-1 has been thought to suppress tumor metastasis. However, elevated systemic levels of TIMP-1 correlate with poor prognosis in cancer patients, suggesting a metastasis-stimulating role of TIMP-1. In colorectal cancer patients, tumor as well as plasma TIMP-1 levels were correlated with synchronous liver metastasis or distant metastasis-associated disease relapse. In mice, high syste...     »
Journal title abbreviation:
Hepatology
Year:
2015
Journal volume:
61
Journal issue:
1
Pages contribution:
238-48
Language:
eng
Fulltext / DOI:
doi:10.1002/hep.27378
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25131778
Print-ISSN:
0270-9139
TUM Institution:
Chirurgische Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Experimentelle Onkologie und Therapieforschung; Institut für Virologie ; Roman Herzog Comprehensive Cancer Center
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