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Title:

Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.

Document type:
Journal Article; Research Support, N.I.H., Extramural
Author(s):
Worthley, Daniel L; Churchill, Michael; Compton, Jocelyn T; Tailor, Yagnesh; Rao, Meenakshi; Si, Yiling; Levin, Daniel; Schwartz, Matthew G; Uygur, Aysu; Hayakawa, Yoku; Gross, Stefanie; Renz, Bernhard W; Setlik, Wanda; Martinez, Ashley N; Chen, Xiaowei; Nizami, Saqib; Lee, Heon Goo; Kang, H Paco; Caldwell, Jon-Michael; Asfaha, Samuel; Westphalen, C Benedikt; Graham, Trevor; Jin, Guangchun; Nagar, Karan; Wang, Hongshan; Kheirbek, Mazen A; Kolhe, Alka; Carpenter, Jared; Glaire, Mark; Nair, Abhina...     »
Abstract:
The stem cells that maintain and repair the postnatal skeleton remain undefined. One model suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts, chondrocytes, marrow stromal cells, and adipocytes, although the existence of these cells has not been proven through fate-mapping experiments. We demonstrate here that expression of the bone morphogenetic protein (BMP) antagonist gremlin 1 defines a population of osteochondroreticular (OCR) stem cells in the bone marrow....     »
Journal title abbreviation:
Cell
Year:
2015
Journal volume:
160
Journal issue:
1-2
Pages contribution:
269-84
Language:
eng
Fulltext / DOI:
doi:10.1016/j.cell.2014.11.042
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25594183
Print-ISSN:
0092-8674
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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