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Title:

Nociceptin effect on intestinal motility depends on opioid-receptor like-1 receptors and nitric oxide synthase co-localization.

Document type:
Journal Article
Author(s):
Sibaev, Andrei; Fichna, Jakub; Saur, Dieter; Yuece, Birol; Timmermans, Jean-Pierre; Storr, Martin
Abstract:
To study the effect of the opioid-receptor like-1 (ORL1) agonist nociceptin on gastrointestinal (GI) myenteric neurotransmission and motility.Reverse transcriptase - polymerase chain reaction and immunohistochemistry were used to localize nociceptin and ORL1 in mouse tissues. Intracellular electrophysiological recordings of excitatory and inhibitory junction potentials (EJP, IJP) were made in a chambered organ bath. Intestinal motility was measured in vivo.Nociceptin accelerated whole and upper...     »
Journal title abbreviation:
World J Gastrointest Pharmacol Ther
Year:
2015
Journal volume:
6
Journal issue:
3
Pages contribution:
73-83
Language:
eng
Fulltext / DOI:
doi:10.4292/wjgpt.v6.i3.73
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26261735
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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