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Title:

Roles of prefrontal cortex and paraventricular thalamus in affective and mechanical components of visceral nociception.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Jurik, Angela; Auffenberg, Eva; Klein, Sabine; Deussing, Jan M; Schmid, Roland M; Wotjak, Carsten T; Thoeringer, Christoph K
Abstract:
Visceral pain represents a major clinical challenge in the management of many gastrointestinal disorders, eg, pancreatitis. However, cerebral neurobiological mechanisms underlying visceral nociception are poorly understood. As a representative model of visceral nociception, we applied cerulein hyperstimulation in C57BL6 mice to induce acute pancreatitis and performed a behavioral test battery and c-Fos staining of brains. We observed a specific pain phenotype and a significant increase in c-Fos...     »
Journal title abbreviation:
Pain
Year:
2015
Journal volume:
156
Journal issue:
12
Pages contribution:
2479-91
Language:
eng
Fulltext / DOI:
doi:10.1097/j.pain.0000000000000318
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26262826
Print-ISSN:
0304-3959
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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