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Titel:

Artery Tertiary Lymphoid Organs Control Aorta Immunity and Protect against Atherosclerosis via Vascular Smooth Muscle Cell Lymphotoxin ? Receptors.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Hu, Desheng; Mohanta, Sarajo K; Yin, Changjun; Peng, Li; Ma, Zhe; Srikakulapu, Prasad; Grassia, Gianluca; MacRitchie, Neil; Dever, Gary; Gordon, Peter; Burton, Francis L; Ialenti, Armando; Sabir, Suleman R; McInnes, Iain B; Brewer, James M; Garside, Paul; Weber, Christian; Lehmann, Thomas; Teupser, Daniel; Habenicht, Livia; Beer, Michael; Grabner, Rolf; Maffia, Pasquale; Weih, Falk; Habenicht, Andreas J R
Abstract:
Tertiary lymphoid organs (TLOs) emerge during nonresolving peripheral inflammation, but their impact on disease progression remains unknown. We have found in aged Apoe(-/-) mice that artery TLOs (ATLOs) controlled highly territorialized aorta T cell responses. ATLOs promoted T cell recruitment, primed CD4(+) T cells, generated CD4(+), CD8(+), T regulatory (Treg) effector and central memory cells, converted naive CD4(+) T cells into induced Treg cells, and presented antigen by an unusual set of d...     »
Zeitschriftentitel:
Immunity
Jahr:
2015
Band / Volume:
42
Heft / Issue:
6
Seitenangaben Beitrag:
1100-15
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.immuni.2015.05.015
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26084025
Print-ISSN:
1074-7613
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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