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Titel:

Fly versus man: evolutionary impairment of nucleolar targeting affects the degradome of Drosophila's Taspase1.

Dokumenttyp:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Wünsch, Désirée; Hahlbrock, Angelina; Heiselmayer, Christina; Bäcker, Sandra; Heun, Patrick; Goesswein, Dorothee; Stöcker, Walter; Schirmeister, Tanja; Schneider, Günter; Krämer, Oliver H; Knauer, Shirley K; Stauber, Roland H
Abstract:
Human Taspase1 is essential for development and cancer by processing critical regulators, such as the mixed-lineage leukemia protein. Likewise, its ortholog, trithorax, is cleaved by Drosophila Taspase1 (dTaspase1), implementing a functional coevolution. To uncover novel mechanism regulating protease function, we performed a functional analysis of dTaspase1 and its comparison to the human ortholog. dTaspase1 contains an essential nucleophile threonine(195), catalyzing cis cleavage into its ?- an...     »
Zeitschriftentitel:
FASEB J
Jahr:
2015
Band / Volume:
29
Heft / Issue:
5
Seitenangaben Beitrag:
1973-85
Sprache:
eng
Volltext / DOI:
doi:10.1096/fj.14-262451
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25634959
Print-ISSN:
0892-6638
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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