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Title:

Maternal vitamin B12 in mice positively regulates bone, but not muscle mass and strength in post-weaning and mature offspring

Document type:
Zeitschriftenaufsatz
Author(s):
Singh, Parminder; Telnova, Svetalana; Zhou, Bin; Mohamed, Abdalla D.; Mello, Vanessa De; Wackerhage, Henning; Guo, X. Edward; Panda, Amulya K.; Yadav, Vijay K.
Abstract:
Vitamin B12 deficiency has been shown to affect bone mass in rodents and negatively impact bone formation in humans. In this study using mouse models, we define the effect of B12 supplementation in the wild-type mother and B12 deficiency in a mouse genetic model (Gif−/− mice) during gestation on bone and muscle architecture and mechanical properties in the offspring. Analysis of bones from 4-wk-old offspring of the wild-type mother following vehicle or B12 supplementation during gestation (from...     »
Dewey Decimal Classification:
610 Medizin und Gesundheit
Journal title:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Year:
2021
Journal volume:
320
Year / month:
2021-06
Quarter:
2. Quartal
Month:
Jun
Journal issue:
6
Pages contribution:
R984-R993
Covered by:
Web of Science
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1152/ajpregu.00355.2020
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33759575
Publisher:
American Physiological Society
E-ISSN:
0363-61191522-1490
Impact Factor:
2,992
Scimago Quartil:
Q2
Notes:
SCImago Journal &  Country Rank
Status:
Erstveröffentlichung
Date of publication:
01.06.2021
Semester:
SS 21
TUM Institution:
Sportbiologie
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