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Title:

Constitutive expression of yes-associated protein (Yap) in adult skeletal muscle fibres induces muscle atrophy and myopathy

Document type:
Zeitschriftenaufsatz
Author(s):
5) Judson RN, Gray SR, Walker C, Carroll AM, Itzstein C, Lionikas AM, Zammit PS, Bari CD, Wackerhage H
Abstract:
The aim of this study was to investigate the function of the Hippo pathway member Yes-associated protein (Yap, gene name Yap1) in skeletal muscle fibres in vivo. Specifically we bred an inducible, skeletal muscle fibre-specific knock-in mouse model (MCK-tTA-hYAP1 S127A) to test whether the over expression of constitutively active Yap (hYAP1 S127A) is sufficient to drive muscle hypertrophy or stimulate changes in fibre type composition. Unexpectedly, after 5-7 weeks of constitutive hYAP1 S127A ov...     »
Dewey Decimal Classification:
570 Biowissenschaften, Biologie; 610 Medizin und Gesundheit
Journal title:
Plos One
Year:
2013
Journal volume:
8
Journal issue:
3
Pages contribution:
e59622
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1371/journal.pone.0059622
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23544078
WWW:
http://aura.abdn.ac.uk/bitstream/handle/2164/3516/Constitutive_expression.pdf%3Bsequence%3D1
E-ISSN:
1932-6203
TUM Institution:
Sportbiologie
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