Impact of inhospital stent thrombosis and cerebrovascular accidents on long-term prognosis after percutaneous coronary intervention.

Guerra, Elena, E; Ndrepepa, Gjin, G; Schulz, Stefanie, S; Byrne, Robert, R; Hoppmann, Petra, P; Kufner, Sebastian, S; Ibrahim, Tareq, T; Tada, Tomohisa, T; Schunkert, Heribert, H; Laugwitz, Karl-Ludwig, KL; Kastrati, Adnan, A

journal article

Titel:: Impact of inhospital stent thrombosis and cerebrovascular accidents on long-term prognosis after percutaneous coronary intervention.
Dokumenttyp:: journal article
Autor(en):: Guerra, Elena, E; Ndrepepa, Gjin, G; Schulz, Stefanie, S; Byrne, Robert, R; Hoppmann, Petra, P; Kufner, Sebastian, S; Ibrahim, Tareq, T; Tada, Tomohisa, T; Schunkert, Heribert, H; Laugwitz, Karl-Ludwig, KL; Kastrati, Adnan, A
Abstract:: Inhospital stent thrombosis (ST) and cerebrovascular accidents (CVA) are rare but serious adverse events after percutaneous coronary intervention (PCI). The association of ST or CVA with long-term outcome after PCI remains poorly investigated.The study included 18,334 consecutive patients who underwent PCI. Patients were divided into 3 groups: the group with ST, the group with CVA, and the group without these events. The primary outcome was all-cause mortality at 3-year follow-up.Inhospital ST or CVA occurred in 59 patients (0.32%) and in 90 patients (0. 49%), respectively. There were 2,149 deaths (11.7%) during the follow-up: 26 deaths among patients with ST, 32 deaths among patients with CVA, and 2,091 deaths among patients without ST or CVA (Kaplan-Meier estimates of 3-year mortality 45.3%, 38.0%, and 12.9%, odds ratio 6.1, 95% CI 3.6-10.2, P< .001 for ST group vs the group without ST or CVA and odds ratio 4.2 [2.7-6.6], P< .001 for CVA group vs the group without ST or CVA). There was no significant difference in the 3-year mortality between CVA and ST groups (P = .29). The Cox proportional hazards model showed that ST (adjusted hazard ratio 4.97, 95% CI 2.58-9.56, P< .001) and CVA (adjusted hazard ratio 2.25 [1.25-4.04], P = .006) were independently associated with the increased risk of 3-year mortality.Inhospital ST and CVA after PCI are associated with the increased risk of 3-year mortality. Both events seem to have a similar impact on long-term survival.
Zeitschriftentitel:: Am Heart J
Jahr:: 2014
Band / Volume:: 168
Heft / Issue:: 6
Seitenangaben Beitrag:: 862-8.e1
Sprache:: eng
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/25458649
Print-ISSN:: 0002-8703
TUM Einrichtung:: I. Medizinische Klinik und Poliklinik
BibTeX

Vorkommen:

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Innere Medizin I, Kardiologie (Prof. Laugwitz)2014