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Title:

PIEZO1 targeting in macrophages boosts phagocytic activity and foam cell apoptosis in atherosclerosis.

Document type:
Journal Article
Author(s):
Pourteymour, Shirin; Fan, Jingxue; Majhi, Rakesh Kumar; Guo, Shuyuan; Sun, Xin; Huang, Zhen; Liu, Ying; Winter, Hanna; Bäcklund, Alexandra; Skenteris, Nikolaos-Taxiarchis; Chernogubova, Ekaterina; Werngren, Olivera; Li, Zhaolong; Skogsberg, Josefin; Li, Yuhuang; Matic, Ljubica; Hedin, Ulf; Maegdefessel, Lars; Ehrenborg, Ewa; Tian, Ye; Jin, Hong
Abstract:
The rising incidences of atherosclerosis have necessitated efforts to identify novel targets for therapeutic interventions. In the present study, we observed increased expression of the mechanosensitive calcium channel Piezo1 transcript in mouse and human atherosclerotic plaques, correlating with infiltration of PIEZO1-expressing macrophages. In vitro administration of Yoda1, a specific agonist for PIEZO1, led to increased foam cell apoptosis and enhanced phagocytosis by macrophages. Mechanistic...     »
Journal title abbreviation:
Cell Mol Life Sci
Year:
2024
Journal volume:
81
Journal issue:
1
Fulltext / DOI:
doi:10.1007/s00018-024-05372-3
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/39107572
Print-ISSN:
1420-682X
TUM Institution:
Professur für Vaskuläre Biologie (Prof. Maegdefessel)
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