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Title:

The long non-coding RNA MEG8 induces an endothelial barrier through regulation of microRNA-370 and -494 processing.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Kremer, Veerle; Stanicek, Laura; van Ingen, Eva; Bink, Diewertje I; Hilderink, Sarah; Tijsen, Anke J; Wittig, Ilka; Mägdefessel, Lars; Nossent, Anne Yaël; Boon, Reinier A
Abstract:
The 14q32 locus is an imprinted region in the human genome which contains multiple non-coding RNAs. We investigated the role of the long non-coding RNA maternally expressed gene 8 (MEG8) in endothelial function and its underlying mechanism. A 5-fold increase in MEG8 was observed with increased passage number in human umbilical vein endothelial cells (HUVECs), suggesting MEG8 is induced during aging. MEG8 knockdown resulted in a 1.8-fold increase in senescence, suggesting MEG8 might be protective...     »
Journal title abbreviation:
J Cell Sci
Year:
2022
Journal volume:
135
Journal issue:
12
Fulltext / DOI:
doi:10.1242/jcs.259671
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35611612
Print-ISSN:
0021-9533
TUM Institution:
Professur für Vaskuläre Biologie (Prof. Maegdefessel)
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