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Titel:

Leukocytes carrying Clonal Hematopoiesis of Indeterminate Potential (CHIP) Mutations invade Human Atherosclerotic Plaques.

Dokumenttyp:
Preprint
Autor(en):
von Scheidt, Moritz; Bauer, Sabine; Ma, Angela; Hao, Ke; Kessler, Thorsten; Vilne, Baiba; Wang, Ying; Hodonsky, Chani J; Ghosh, Saikat K B; Mokry, Michal; Gao, Hua; Kawai, Kenji; Sakamoto, Atsushi; Kaiser, Juliane; Bongiovanni, Dario; Fleig, Julia; Oldenbuettel, Lilith; Chen, Zhifen; Moggio, Aldo; Sager, Hendrik B; Hecker, Judith S; Bassermann, Florian; Maegdefessel, Lars; Miller, Clint L; Koenig, Wolfgang; Zeiher, Andreas M; Dimmeler, Stefanie; Graw, Matthias; Braun, Christian; Ruusalepp, Arno;...     »
Abstract:
BACKGROUND: Leukocyte progenitors derived from clonal hematopoiesis of undetermined potential (CHIP) are associated with increased cardiovascular events. However, the prevalence and functional relevance of CHIP in coronary artery disease (CAD) are unclear, and cells affected by CHIP have not been detected in human atherosclerotic plaques. METHODS: CHIP mutations in blood and tissues were identified by targeted deep-DNA-sequencing (DNAseq: coverage >3,000) and whole-genome-sequencing (WGS: covera...     »
Zeitschriftentitel:
medRxiv
Jahr:
2023
Volltext / DOI:
doi:10.1101/2023.07.22.23292754
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37546840
TUM Einrichtung:
Professur für Vaskuläre Biologie (Prof. Maegdefessel)
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