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Titel:

Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Autor(en):
Flores, Alyssa M; Hosseini-Nassab, Niloufar; Jarr, Kai-Uwe; Ye, Jianqin; Zhu, Xingjun; Wirka, Robert; Koh, Ai Leen; Tsantilas, Pavlos; Wang, Ying; Nanda, Vivek; Kojima, Yoko; Zeng, Yitian; Lotfi, Mozhgan; Sinclair, Robert; Weissman, Irving L; Ingelsson, Erik; Smith, Bryan Ronain; Leeper, Nicholas J
Abstract:
Atherosclerosis is the process that underlies heart attack and stroke. A characteristic feature of the atherosclerotic plaque is the accumulation of apoptotic cells in the necrotic core. Prophagocytic antibody-based therapies are currently being explored to stimulate the phagocytic clearance of apoptotic cells; however, these therapies can cause off-target clearance of healthy tissues, which leads to toxicities such as anaemia. Here we developed a macrophage-specific nanotherapy based on single...     »
Zeitschriftentitel:
Nat Nanotechnol
Jahr:
2020
Band / Volume:
15
Heft / Issue:
2
Seitenangaben Beitrag:
154-161
Volltext / DOI:
doi:10.1038/s41565-019-0619-3
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31988506
Print-ISSN:
1748-3387
TUM Einrichtung:
Fachgebiet Gefäßchirurgie (Prof. Eckstein)
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