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Titel:

High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis.

Dokumenttyp:
Preprint
Autor(en):
Bashore, Alexander C; Yan, Hanying; Xue, Chenyi; Zhu, Lucie Y; Kim, Eunyoung; Mawson, Thomas; Coronel, Johana; Chung, Allen; Ho, Sebastian; Ross, Leila S; Kissner, Michael; Passegué, Emmanuelle; Bauer, Robert C; Maegdefessel, Lars; Li, Mingyao; Reilly, Muredach P
Abstract:
BACKGROUND: Atherosclerotic plaques are complex tissues composed of a heterogeneous mixture of cells. However, we have limited understanding of the comprehensive transcriptional and phenotypical landscape of the cells within these lesions. METHODS: To characterize the landscape of human carotid atherosclerosis in greater detail, we combined cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) and single-cell RNA sequencing (scRNA-seq) to classify all cell types within lesion...     »
Zeitschriftentitel:
medRxiv
Jahr:
2023
Volltext / DOI:
doi:10.1101/2023.07.13.23292633
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/37502836
TUM Einrichtung:
Professur für Vaskuläre Biologie (Prof. Maegdefessel)
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