Benutzer: Gast  Login
Titel:

Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Wang, Ying; Nanda, Vivek; Direnzo, Daniel; Ye, Jianqin; Xiao, Sophia; Kojima, Yoko; Howe, Kathryn L; Jarr, Kai-Uwe; Flores, Alyssa M; Tsantilas, Pavlos; Tsao, Noah; Rao, Abhiram; Newman, Alexandra A C; Eberhard, Anne V; Priest, James R; Ruusalepp, Arno; Pasterkamp, Gerard; Maegdefessel, Lars; Miller, Clint L; Lind, Lars; Koplev, Simon; Björkegren, Johan L M; Owens, Gary K; Ingelsson, Erik; Weissman, Irving L; Leeper, Nicholas J
Abstract:
Atherosclerosis is the process underlying heart attack and stroke. Despite decades of research, its pathogenesis remains unclear. Dogma suggests that atherosclerotic plaques expand primarily via the accumulation of cholesterol and inflammatory cells. However, recent evidence suggests that a substantial portion of the plaque may arise from a subset of "dedifferentiated" vascular smooth muscle cells (SMCs) which proliferate in a clonal fashion. Herein we use multicolor lineage-tracing models to co...     »
Zeitschriftentitel:
Proc Natl Acad Sci U S A
Jahr:
2020
Band / Volume:
117
Heft / Issue:
27
Seitenangaben Beitrag:
15818-15826
Volltext / DOI:
doi:10.1073/pnas.2006348117
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32541024
Print-ISSN:
0027-8424
TUM Einrichtung:
Fachgebiet Gefäßchirurgie (Prof. Eckstein)
 BibTeX