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Title:

Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Author(s):
Sennblad, Bengt; Basu, Saonli; Mazur, Johanna; Suchon, Pierre; Martinez-Perez, Angel; van Hylckama Vlieg, Astrid; Truong, Vinh; Li, Yuhuang; Gådin, Jesper R; Tang, Weihong; Grossman, Vera; de Haan, Hugoline G; Handin, Niklas; Silveira, Angela; Souto, Juan Carlos; Franco-Cereceda, Anders; Morange, Pierre-Emmanuel; Gagnon, France; Soria, José Manuel; Eriksson, Per; Hamsten, Anders; Maegdefessel, Lars; Rosendaal, Frits R; Wild, Philipp; Folsom, Aaron R; Tregouet, David-Alexandre; Sabater-Lleal, Mar...     »
Abstract:
Coagulation factor XI (FXI) has become increasingly interesting for its role in pathogenesis of thrombosis. While elevated plasma levels of FXI have been associated with venous thromboembolism and ischemic stroke, its deficiency is associated with mild bleeding. We aimed to determine novel genetic and post-transcriptional plasma FXI regulators.We performed a genome-wide association study (GWAS) for plasma FXI levels, using novel data imputed to the 1000 Genomes reference panel. Individual GWAS a...     »
Journal title abbreviation:
Hum Mol Genet
Year:
2017
Journal volume:
26
Journal issue:
3
Pages contribution:
637-649
Language:
eng
Fulltext / DOI:
doi:10.1093/hmg/ddw401
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28053049
Print-ISSN:
0964-6906
TUM Institution:
Fachgebiet Gefäßchirurgie (Prof. Eckstein)
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