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Document type:
journal article
Author(s):
Björck, Hanna M; Du, Lei; Pulignani, Silvia; Paloschi, Valentina; Lundströmer, Karin; Kostina, Alexandra S; Österholm, Cecilia; Malashicheva, Anna; Kostareva, Anna; Evangelista, Arturo; Teixidó-Tura, Gisela; Maleki, Shohreh; Franco-Cereceda, Anders; Eriksson, Per; Mechanistic Interrogation of Bicuspid Aortic Valve associated Aortopathy (MIBAVA) Leducq Consortium; Dietz, Harry C; Loeys, Bart; Van Laer, Lut; McCallion, Andrew S; Mertens, Luc; Mital, Seema; Mohamed, Salah A; Andelfinger, Gregor
Title:
Altered DNA methylation indicates an oscillatory flow mediated epithelial-to-mesenchymal transition signature in ascending aorta of patients with bicuspid aortic valve.
Abstract:
Disturbed flow has been suggested to contribute to aneurysm susceptibility in bicuspid aortic valve (BAV) patients. Lately, flow has emerged as an important modulator of DNA methylation. Hear we combined global methylation analysis with in vitro studies of flow-sensitive methylation to identify biological processes associated with BAV-aortopathy and the potential contribution of flow. Biopsies from non-dilated and dilated ascending aortas were collected from BAV (n = 21) and tricuspid aortic val...     »
Journal title abbreviation:
Sci Rep
Year:
2018
Journal volume:
8
Journal issue:
1
Pages contribution:
2777
Language:
eng
Fulltext / DOI:
doi:10.1038/s41598-018-20642-4
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29426841
TUM Institution:
Klinik und Poliklinik für Vaskuläre und Endovaskuläre Chirurgie
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