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Title:

Parallel Murine and Human Aortic Wall Genomics Reveals Metabolic Reprogramming as Key Driver of Abdominal Aortic Aneurysm Progression.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Gäbel, Gabor; Northoff, Bernd H; Balboa, Amanda; Becirovic-Agic, Mediha; Petri, Marcelo; Busch, Albert; Maegdefessel, Lars; Mahlmann, Adrian; Ludwig, Stefan; Teupser, Daniel; de Waard, Vivian; Golledge, Jonathan; Wanhainen, Anders; Wågsäter, Dick; Holdt, Lesca M; Lindeman, Jan H N
Abstract:
Background While numerous interventions effectively interfered with abdominal aortic aneurysm (AAA) formation/progression in preclinical models, none of the successes translated into clinical success. Hence, a systematic exploration of parallel and divergent processes in clinical AAA disease and its 2 primary models (the porcine pancreatic elastase and angiotensin-II infusion [AngII] murine model) was performed to identify mechanisms relevant for aneurysm disease. Methods and Results This study...     »
Journal title abbreviation:
J Am Heart Assoc
Year:
2021
Journal volume:
10
Journal issue:
17
Fulltext / DOI:
doi:10.1161/JAHA.120.020231
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34420357
Print-ISSN:
2047-9980
TUM Institution:
Fachgebiet Gefäßchirurgie (Prof. Eckstein)
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