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Dokumenttyp:
Journal Article; Article
Autor(en):
Di Gennaro, Antonio; Araújo, Ana Carolina; Busch, Albert; Jin, Hong; Wågsäter, Dick; Vorkapic, Emina; Caidahl, Kenneth; Eriksson, Per; Samuelsson, Bengt; Maegdefessel, Lars; Haeggström, Jesper Z
Titel:
Cysteinyl leukotriene receptor 1 antagonism prevents experimental abdominal aortic aneurysm.
Abstract:
Cysteinyl-leukotrienes (cys-LTs) are 5-lipoxygenase-derived lipid mediators involved in the pathogenesis and progression of inflammatory disorders, in particular asthma. We have previously found evidence linking these mediators to increased levels of proteolytic enzymes in tissue specimens of human abdominal aortic aneurysm (AAA). Here we show that antagonism of the CysLT1 receptor by montelukast, an established antiasthma drug, protects against a strong aorta dilatation (>50% increase = aneurys...     »
Zeitschriftentitel:
Proc Natl Acad Sci U S A
Jahr:
2018
Band / Volume:
115
Heft / Issue:
8
Seitenangaben Beitrag:
1907-1912
Sprache:
eng
Volltext / DOI:
doi:10.1073/pnas.1717906115
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29432192
Print-ISSN:
0027-8424
TUM Einrichtung:
Fachgebiet Gefäßchirurgie (Prof. Eckstein)
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