Intraoperative completion studies in carotid endarterectomy: systematic review and meta-analysis of techniques and outcomes.

Knappich, Christoph; Lang, Thomas; Tsantilas, Pavlos; Schmid, Sofie; Kallmayer, Michael; Haller, Bernhard; Eckstein, Hans-Henning

doi:10.21037/atm-20-2931

Benutzer: Gast

Klinik und Poliklinik für Vaskuläre und Endovaskuläre Chirurgie (Prof. Eckstein)

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Dokumenttyp:: Journal Article
Autor(en):: Knappich, Christoph; Lang, Thomas; Tsantilas, Pavlos; Schmid, Sofie; Kallmayer, Michael; Haller, Bernhard; Eckstein, Hans-Henning
Titel:: Intraoperative completion studies in carotid endarterectomy: systematic review and meta-analysis of techniques and outcomes.
Abstract:: BACKGROUND: Declining perioperative stroke and death rates over the past 3 decades have been paralleled by an increasing use of intraoperative completion studies (ICS) following carotid endarterectomy (CEA). Techniques applied include angiography, intraoperative duplex ultrasound (IDUS), flowmetry, and angioscopy. This systematic review and meta-analysis is aiming on providing an overview of techniques and corresponding outcomes. METHODS: A PubMed based systematic literature review comprising the years 1980 through 2020 was performed using predefined keywords to identify articles on different ICS techniques. Pooled analyses and meta-analyses estimating risk ratios (RR) and 95% confidence intervals (CI) were performed to compare outcomes of different ICS modes to nonapplication of any ICS. I2 values were assessed to quantify study heterogeneities. RESULTS: Identification of 34 studies including patients undergoing CEA with angiography (n=53,218), IDUS (n=20,030), flowmetry (n=16,812), and angioscopy (n=2,291). Corresponding rates of perioperative stroke were 1.5%, 1.8%, 3.6%, and 1.5%, perioperative stroke or death occurred in 1.7%, 1.9%, 2.2%, and 2.0%. Intraoperative surgical revision rates were 6.2%, 5.9%, and 7.9% after CEA with angiography, IDUS, and angioscopy, respectively. Compared to nonapplication of any ICS, the pooled analysis revealed angiography to be significantly associated with lower rates of stroke (RR 0.47; 95% CI, 0.36-0.62; P<0.0001) and stroke or death (RR 0.76; 95% CI, 0.70-0.83; P<0.0001). IDUS was significantly associated with lower rates of stroke (RR 0.56; 95% CI, 0.43-0.73; P<0.0001) and stroke or death (RR 0.83; 95% CI, 0.74-0.93; P=0.0018), whereas angioscopy showed a significant association with a lower stroke rate (RR 0.48; 95% CI, 0.033-0.68; P=0.0001), but no effect on the combined stroke or death rate. Angioscopy was associated with a higher intraoperative revision rate compared to angiography (RR 1.29; 95% CI, 1.07-1.54; P=0.006). The meta-analyses confirmed lower perioperative stroke or death rates for angiography (RR 0.83; 95% CI, 0.76-0.91) and IDUS (RR 0.86; 95% CI, 0.76-0.98) compared to non-application of any ICS, whereas flowmetry showed no significant association. CONCLUSIONS: This study represents the first systematic literature review and meta-analysis on usage of ICSs in CEA. Data strongly indicate a significant beneficial effect of angiography, IDUS, and angioscopy on perioperative CEA outcomes. Any carotid surgeon should consider implementation of ICSs in his routine armamentarium.
Zeitschriftentitel:: Ann Transl Med
Jahr:: 2021
Band / Volume:: 9
Heft / Issue:: 14
Volltext / DOI:: doi:10.21037/atm-20-2931
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/34430642
Print-ISSN:: 2305-5839
TUM Einrichtung:: Fachgebiet Gefäßchirurgie (Prof. Eckstein); Institut für Medizinische Statistik und Epidemiologie
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