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Titel:

Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Autor(en):
Sennblad, Bengt; Basu, Saonli; Mazur, Johanna; Suchon, Pierre; Martinez-Perez, Angel; van Hylckama Vlieg, Astrid; Truong, Vinh; Li, Yuhuang; Gådin, Jesper R; Tang, Weihong; Grossman, Vera; de Haan, Hugoline G; Handin, Niklas; Silveira, Angela; Souto, Juan Carlos; Franco-Cereceda, Anders; Morange, Pierre-Emmanuel; Gagnon, France; Soria, José Manuel; Eriksson, Per; Hamsten, Anders; Maegdefessel, Lars; Rosendaal, Frits R; Wild, Philipp; Folsom, Aaron R; Tregouet, David-Alexandre; Sabater-Lleal, Mar...     »
Abstract:
Coagulation factor XI (FXI) has become increasingly interesting for its role in pathogenesis of thrombosis. While elevated plasma levels of FXI have been associated with venous thromboembolism and ischemic stroke, its deficiency is associated with mild bleeding. We aimed to determine novel genetic and post-transcriptional plasma FXI regulators.We performed a genome-wide association study (GWAS) for plasma FXI levels, using novel data imputed to the 1000 Genomes reference panel. Individual GWAS a...     »
Zeitschriftentitel:
Hum Mol Genet
Jahr:
2017
Band / Volume:
26
Heft / Issue:
3
Seitenangaben Beitrag:
637-649
Sprache:
eng
Volltext / DOI:
doi:10.1093/hmg/ddw401
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28053049
Print-ISSN:
0964-6906
TUM Einrichtung:
Fachgebiet Gefäßchirurgie (Prof. Eckstein)
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