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Title:

A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes.

Document type:
Journal Article; 5
Author(s):
de la Rosa, Jorge; Weber, Julia; Friedrich, Mathias Josef; Li, Yilong; Rad, Lena; Ponstingl, Hannes; Liang, Qi; de Quirós, Sandra Bernaldo; Noorani, Imran; Metzakopian, Emmanouil; Strong, Alexander; Li, Meng Amy; Astudillo, Aurora; Fernández-García, María Teresa; Fernández-García, María Soledad; Hoffman, Gary J; Fuente, Rocío; Vassiliou, George S; Rad, Roland; López-Otín, Carlos; Bradley, Allan; Cadiñanos, Juan
Abstract:
The overwhelming number of genetic alterations identified through cancer genome sequencing requires complementary approaches to interpret their significance and interactions. Here we developed a novel whole-body insertional mutagenesis screen in mice, which was designed for the discovery of Pten-cooperating tumor suppressors. Toward this aim, we coupled mobilization of a single-copy inactivating Sleeping Beauty transposon to Pten disruption within the same genome. The analysis of 278 transpositi...     »
Journal title abbreviation:
Nat Genet
Year:
2017
Journal volume:
49
Journal issue:
5
Pages contribution:
730-741
Fulltext / DOI:
doi:10.1038/ng.3817
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28319090
Print-ISSN:
1061-4036
TUM Institution:
Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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