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Title:

Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Haimovici, Aladin; Höfer, Christoph; Badr, Mohamed Tarek; Bavafaye Haghighi, Elham; Amer, Tarek; Boerries, Melanie; Bronsert, Peter; Glavynskyi, Ievgen; Fanfone, Deborah; Ichim, Gabriel; Thilmany, Nico; Weber, Arnim; Brummer, Tilman; Spohr, Corinna; Öllinger, Rupert; Janssen, Klaus-Peter; Rad, Roland; Häcker, Georg
Abstract:
Micronuclei are DNA-containing structures separate from the nucleus found in cancer cells. Micronuclei are recognized by the immune sensor axis cGAS/STING, driving cancer metastasis. The mitochondrial apoptosis apparatus can be experimentally triggered to a non-apoptotic level, and this can drive the appearance of micronuclei through the Caspase-activated DNAse (CAD). We tested whether spontaneously appearing micronuclei in cancer cells are linked to sub-lethal apoptotic signals. Inhibition of m...     »
Journal title abbreviation:
Cell Death Dis
Year:
2022
Journal volume:
13
Journal issue:
4
Fulltext / DOI:
doi:10.1038/s41419-022-04768-y
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35393399
TUM Institution:
Klinik und Poliklinik für Chirurgie; Professur für Molekulare Onkologie und Funktionelle Genomik (Prof. Rad)
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