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Title:

Functional analysis of peripheral and intratumoral neoantigen-specific TCRs identified in a patient with melanoma.

Document type:
Journal Article
Author(s):
Bräunlein, Eva; Lupoli, Gaia; Füchsl, Franziska; Abualrous, Esam T; de Andrade Krätzig, Niklas; Gosmann, Dario; Wietbrock, Lukas; Lange, Sebastian; Engleitner, Thomas; Lan, Huan; Audehm, Stefan; Effenberger, Manuel; Boxberg, Melanie; Steiger, Katja; Chang, Yinshui; Yu, Kai; Atay, Cigdem; Bassermann, Florian; Weichert, Wilko; Busch, Dirk H; Rad, Roland; Freund, Christian; Antes, Iris; Krackhardt, Angela M
Abstract:
BACKGROUND: Neoantigens derived from somatic mutations correlate with therapeutic responses mediated by treatment with immune checkpoint inhibitors. Neoantigens are therefore highly attractive targets for the development of therapeutic approaches in personalized medicine, although many aspects of their quality and associated immune responses are not yet well understood. In a case study of metastatic malignant melanoma, we aimed to perform an in-depth characterization of neoantigens and respectiv...     »
Journal title abbreviation:
J Immunother Cancer
Year:
2021
Journal volume:
9
Journal issue:
9
Fulltext / DOI:
doi:10.1136/jitc-2021-002754
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34518289
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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