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Title:

Angiocrine Hepatocyte Growth Factor Signaling Controls Physiological Organ and Body Size and Dynamic Hepatocyte Proliferation to Prevent Liver Damage during Regeneration.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Zhang, Xue-Jun; Olsavszky, Victor; Yin, Yuhan; Wang, Baocai; Engleitner, Thomas; Öllinger, Rupert; Schledzewski, Kai; Koch, Philipp-Sebastian; Rad, Roland; Schmid, Roland M; Friess, Helmut; Goerdt, Sergij; Hüser, Norbert; Géraud, Cyrill; von Figura, Guido; Hartmann, Daniel
Abstract:
Liver sinusoidal endothelial cells (LSECs) control organ functions, metabolism, and development through the secretion of angiokines. LSECs express hepatocyte growth factor (Hgf), which is involved in prenatal development, metabolic homeostasis, and liver regeneration. This study aimed to elucidate the precise contribution of LSEC-derived Hgf in physiological homeostasis and liver regeneration. Stab2-iCretg/wt; Hgffl/fl (HgfΔLSEC) mice were generated to abrogate Hgf expression selectively in LSEC...     »
Journal title abbreviation:
Am J Pathol
Year:
2020
Journal volume:
190
Journal issue:
2
Pages contribution:
358-371
Fulltext / DOI:
doi:10.1016/j.ajpath.2019.10.009
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31783007
Print-ISSN:
0002-9440
TUM Institution:
Chirurgische Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik (Gastroenterologie); Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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