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Titel:

Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Dietachmayr, Michael; Rathakrishnan, Abirami; Karpiuk, Oleksandra; von Zweydorf, Felix; Engleitner, Thomas; Fernández-Sáiz, Vanesa; Schenk, Petra; Ueffing, Marius; Rad, Roland; Eilers, Martin; Gloeckner, Christian Johannes; Clemm von Hohenberg, Katharina; Bassermann, Florian
Abstract:
Regulation of mitosis secures cellular integrity and its failure critically contributes to the development, maintenance, and treatment resistance of cancer. In yeast, the dual phosphatase Cdc14 controls mitotic progression by antagonizing Cdk1-mediated protein phosphorylation. By contrast, specific mitotic functions of the mammalian Cdc14 orthologue CDC14B have remained largely elusive. Here, we find that CDC14B antagonizes CDK1-mediated activating mitotic phosphorylation of the deubiquitinase U...     »
Zeitschriftentitel:
Nat Commun
Jahr:
2020
Band / Volume:
11
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41467-020-15059-5
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32152317
Print-ISSN:
2041-1723
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Professur für Translationale gastroenterologische Onkologie (Prof. Rad)
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