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Title:

Development and Evaluation of MR-Based Radiogenomic Models to Differentiate Atypical Lipomatous Tumors from Lipomas.

Document type:
Journal Article
Author(s):
Foreman, Sarah C; Llorián-Salvador, Oscar; David, Diana E; Rösner, Verena K N; Rischewski, Jon F; Feuerriegel, Georg C; Kramp, Daniel W; Luiken, Ina; Lohse, Ann-Kathrin; Kiefer, Jurij; Mogler, Carolin; Knebel, Carolin; Jung, Matthias; Andrade-Navarro, Miguel A; Rost, Burkhard; Combs, Stephanie E; Makowski, Marcus R; Woertler, Klaus; Peeken, Jan C; Gersing, Alexandra S
Abstract:
BACKGROUND: The aim of this study was to develop and validate radiogenomic models to predict the MDM2 gene amplification status and differentiate between ALTs and lipomas on preoperative MR images. METHODS: MR images were obtained in 257 patients diagnosed with ALTs (n = 65) or lipomas (n = 192) using histology and the MDM2 gene analysis as a reference standard. The protocols included T2-, T1-, and fat-suppressed contrast-enhanced T1-weighted sequences. Additionally, 50 patients were obtained fr...     »
Journal title abbreviation:
Cancers (Basel)
Year:
2023
Journal volume:
15
Journal issue:
7
Fulltext / DOI:
doi:10.3390/cancers15072150
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37046811
TUM Institution:
595; 596; Institut für Allgemeine Pathologie und Pathologische Anatomie (Dr. Mogler komm.); Institut für Diagnostische und Interventionelle Radiologie (Prof. Makowski); Klinik und Poliklinik für Orthopädie und Sportorthopädie (Prof. von Eisenhart-Rothe); Klinik und Poliklinik für RadioOnkologie und Strahlentherapie (Prof. Combs)
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