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Title:

Rapamycin rescues loss of function in blood-brain barrier-interacting Tregs.

Document type:
Journal Article
Author(s):
Baeten, Paulien; Hamad, Ibrahim; Hoeks, Cindy; Hiltensperger, Michael; Van Wijmeersch, Bart; Popescu, Veronica; Aly, Lilian; Somers, Veerle; Korn, Thomas; Kleinewietfeld, Markus; Hellings, Niels; Broux, Bieke
Abstract:
In autoimmunity, FOXP3+ Tregs skew toward a proinflammatory, nonsuppressive phenotype and are, therefore, unable to control the exaggerated autoimmune response. This largely affects the success of autologous Treg therapy, which is currently under investigation for autoimmune diseases, including multiple sclerosis (MS). There is a need to ensure in vivo Treg stability before successful application of Treg therapy. Using genetic fate-mapping mice, we demonstrate that inflammatory, cytokine-express...     »
Journal title abbreviation:
JCI Insight
Year:
2024
Journal volume:
9
Journal issue:
7
Fulltext / DOI:
doi:10.1172/jci.insight.167457
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/38386413
Print-ISSN:
2379-3708
TUM Institution:
Klinik und Poliklinik für Neurologie (Prof. Hemmer); Molekulare Immunologie (Prof. Knolle)
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