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Title:

Reactive oxygen species produced by myeloid cells in psoriasis as a potential biofactor contributing to the development of vascular inflammation.

Document type:
Article; Journal Article
Author(s):
Schaller, Theresa; Ringen, Julia; Fischer, Berenice; Bieler, Tabea; Perius, Katharina; Knopp, Tanja; Kommoss, Katharina S; Korn, Thomas; Heikenwälder, Mathias; Oelze, Matthias; Daiber, Andreas; Münzel, Thomas; Kramer, Daniela; Wenzel, Philip; Wild, Johannes; Karbach, Susanne; Waisman, Ari
Abstract:
Psoriasis is an immune-mediated inflammatory skin disease driven by interleukin-17A (IL-17A) and associated with cardiovascular dysfunction. We used a severe psoriasis mouse model of keratinocyte IL-17A overexpression (K14-IL-17Aind/+ , IL-17Aind/+ control mice) to investigate the activity of neutrophils and a potential cellular interconnection between skin and vasculature. Levels of dermal reactive oxygen species (ROS) and their release by neutrophils were measured by lucigenin-/luminol-based a...     »
Journal title abbreviation:
Biofactors
Year:
2023
Journal volume:
49
Journal issue:
4
Pages contribution:
861-874
Fulltext / DOI:
doi:10.1002/biof.1949
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/37139784
Print-ISSN:
0951-6433
TUM Institution:
Molekulare Immunologie (Prof. Knolle)
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